A POWERFUL RESEARCH AND
            DEVELOPMENT ENGINE

            Our unique ability to repeatedly and consistently translate science into medicine has led to a robust pipeline of clinical-stage medicines, all of which were discovered in our laboratories. Our investigational treatments target allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neuromuscular diseases, infectious diseases and rare diseases.

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            Regeneron Pipeline: Phase 1 Medicines Regeneron Pipeline: Phase 1 Medicines
            • REGN-COV2
              SARS-CoV-2 Antibodies Treatment for hospitalized patients and non-hospitalized patients with COVID-19
            • CEMIPLIMAB*
              PD-1 Antibody Cancer
            • REGN3767
              LAG-3 Antibody Solid tumors, advanced hematologic malignancies
            • REGN1979
              CD20 X CD3 Antibody B-cell malignancies
            • REGN4018*
              MUC16 X CD3 Antibody Platinum-resistant ovarian cancer
            • REGN5458*
              BCMA X CD3 Antibody Multiple myeloma
            • REGN5459*
              BCMA X CD3 Antibody Multiple myeloma
            • REGN5678
              PSMA X CD28 Antibody Prostate cancer
            • REGN5093
              MET X MET Antibody MET-altered advanced non-small cell lung cancer (NSCLC)
            • REGN5713-5714-5715
              Bet v 1 Antibodies Birch Allergy
            Regeneron Pipeline: Phase 2 Medicines Regeneron Pipeline: Phase 2 Medicines
            • AFLIBERCEPT
              VEGF-Trap High-dose (8mg) for wet age-related macular degeneration (AMD)
            • CEMIPLIMAB*
              PD-1 Antibody Basal cell carcinoma (BCC), metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC), neoadjuvant CSCC
            • REGN1979
              CD20 X CD3 Antibody B-cell non-Hodgkin lymphoma
            • SARILUMAB*
              IL-6R Antibody Polyarticular-course juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis
            • DUPILUMAB*
              IL-4R Antibody Grass allergy, peanut allergy
            • REGN1908-1909
              Fel d 1 Antibodies Cat allergy
            • REGN3500*
              IL-33 Antibody Asthma, chronic obstructive pulmonary disease (COPD)
            • REGN5069
              GFRα3 Antibody Osteoarthritis pain of the knee
            • GARETOSMAB
              Activin A Antibody Fibrodysplasia Ossificans Progressiva (FOP)
            • EVINACUMAB
              ANGPTL-3 Antibody Refractory hypercholesterolemia (both HeFH and non-FH), severe hypertriglyceridemia
            • POZELIMAB
              C5 Antibody Paroxysmal nocturnal hemoglobinuria, CD-55 deficient protein-losing enteropathy
            • REGN4461
              LEPR Antibody Generalized lipodystrophy
            Regeneron Pipeline: Phase 3 Medicines Regeneron Pipeline: Phase 3 Medicines
            • AFLIBERCEPT
              VEGF-Trap Retinopathy of prematurity (ROP)
            • CEMIPLIMAB*
              PD-1 Antibody non-small cell lung cancer (NSCLC), cervical cancer, adjuvant cutaneous squamous cell carcinoma (CSCC)
            • ALIROCUMAB
              PCSK9 Antibody Homozygous familial hypercholesterolemia (HoFH) in adults and pediatric patients, heterozygous familial hypercholesterolemia in pediatric patients
            • EVINACUMAB
              ANGPTL-3 Antibody Homozygous familial hypercholesterolemia (HoFH)
            • DUPILUMAB*
              IL-4R Antibody Atopic dermatitis in pediatric patients 6 mo.–11 y.o., asthma in pediatric patients 6-11 y.o., eosinophilic esophagitis, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, prurigo nodularis, chronic spontaneous urticaria
            • SARILUMAB*
              IL-6R Antibody Hospitalized "critical" COVID-19 patients, polymyalgia rheumatica, giant cell arteritis
            • REGN-EB3
              Ebola Virus Antibodies Ebola virus infection
            • FASINUMAB?
              NGF Antibody Osteoarthritis pain of the knee or hip

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            * In collaboration with Sanofi

            ? In collaboration with Teva and Mitsubishi Tanabe

            This graphic displays pipeline drug candidates currently undergoing clinical testing in a variety of diseases. The safety and efficacy of these drug candidates have not been fully evaluated by any regulatory authorities for the indications described in this section.

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